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Title: Discovery of Lead Molecules from Natural Sources Targeting Pro inflammatory Cytokines
Guide(s): A. Sajeli Begum
Keywords: Lead Molecules, Natural Sources, Pro-inflammatory Cytokines
University: Birla Institute of Technology and Science
Completed Date: 
Abstract: Dysregulation of key pro-inflammatory cytokines like tumour necrosis factor-and#945;, newlineinterleukin-1and#946; and interleukin-6 causes chronic inflammation resulting in fibrosis and tissue newlinenecrosis. The persistent chronic inflammation increases the development of the degenerative newlinediseases such as rheumatoid arthritis, atherosclerosis, heart disease, alzheimer, asthma, acquired newlineimmunodeficiency disorder, cancer, congestive heart failure, multiple sclerosis, diabetes, newlineinfections (bacteria, fungi, parasites), gout, inflammatory bowel disease, aging and other newlineneurodegenerative central nervous system depression, all of which are associated with newlineimmunopathological conditions that play a key role in the onset of the condition. Therefore these newlinecytokines were targeted in the development of anti-inflammatory therapies. Several extensive newlineresearch reports had revealed that blocking of TNF-and#945;, IL-1and#946; and / or IL-6 were found to be newlineefficacious for many patients. Thus, agents that suppress the expression of these cytokines will newlinehave the potential for alleviating inflammatory processes leading to diseases. newlineIn the present research work, attempts were made to discover low molecular weight newlinecytokine inhibitory leads from two different natural sources targeting microorganism and plants. newlineBased on literature review, Pseudomonas and Abutilon indicum were selected for the study. A newlinePseudomonas bacteria identified as P. aeruginosa 16S ribosomal RNA gene was isolated from newlinethe soil and the ethyl acetate extract of its culture broth (EEPA) was prepared. The newlinechromatographic purification of EEPA yielded four cyclic dipeptides characterized as cyclo(LProline- newlineGlycine) (PA-1), cyclo(L-Proline-L-Phenylalanine) (PA-2), cyclo(trans-4-hydroxy-LProline- newlineL-Phenylalanine) (PA-3), cyclo(trans-4-hydroxy-L-Proline-L-Leucine) (PA-4). Isolation newlineof these 2,5-dioxopiperazine derivatives from the culture broth of P. aeruginosa is reported for newline! viiiquot newlinethe first time. The chemical investigation on aerial parts of Abutilon indicum lead to the isolation newlineof five aromatic compounds, c
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Appears in Departments:Pharmacy

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