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Title: Chemical and Cytotoxic Studies on Oldenlandia umbellata inn and Analytical Investigation on Carthamus tinctorius Linn
Researcher: Mahibalan S
Guide(s): A. Sajeli Begum
Keywords: Chemical and Cytotoxic, Oldenlandia umbellata Linn., Carthamus tinctorius Linn.
University: Birla Institute of Technology and Science
Completed Date: 
Abstract: In the present study we carried out chemical investigation and cytotoxic studies on newlineOldenlandia umbellata L. and its constituents along with quality evaluation and newlinestandardization of different Indian varieties of Carthamus tinctorius. The results were newlinepresented in two parts, part-I and part-II. newlinePART I newlinePlants have an antiquity of use in health care system and a significant number of newlinedrugs have been derived from them. Plants of Oldenlandia genus like O. diffusa and O. newlinecorymbosa have been extensively used in Traditional Chinese Medicine to treat cancers and newlinedeclared as endangered species. A similar Indian species of Oldenlandia genus, O. umbellata newlinewas selected for the investigation with the aim if it can become a substitute for O. diffusa. As newlinea first step, microscopic analysis of stem and leaves of O. umbellata was performed to newlineestablish distinct identification features of this species. Then, LC-PDA-ESI-MS based newlinechemical investigation following chromatographic separation of methanolic extract (HUM) newlineof O. umbellata and its fractions HUM-E and HUM-B were carried out which yielded twelve newlinepure compounds. newlineBased on the various spectroscopic analyses of isolated compounds, the structure newlineelucidation was carried out. A novel symmetrical coumarin dimer named as oledicoumarin newline(1), together with eleven known compounds, pheophorbide A methyl ester (2), cedrelopsin newline(3), ursolic acid (4), 1,2-dimethoxy-3-hydroxy-9,10-anthracenedione (5), 1,3-dimethoxy-2- newlinehydroxy anthraquinone (6), hedyotiscone B (7), asperulosidic acid (8), deacetyl asperuloside newline(9), feretoside (10), scandoside (11) and 6and#945;-hydroxygeniposide (12) were determined. newlineCompounds 2 and 3 are reported for the first time from O. umbellata and as well Rubiaceae newlinev newlineplants. Also, this is the second scientific report of isolation of compound 7 from natural newlinesources. The occurrence of compounds 8-12 in O. umbellata is also explored for the first time newlinethrough the present investigation. newlineThe study further explored the cytotoxic effect of methanolic extract (HUM) of O. newlineumbellata and i
Pagination: 10.3 MB
Appears in Departments:Pharmacy

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