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Title: Elicitation and synthesis of bioactive compounds and evaluation of their biological activities
Researcher: Anand M
Guide(s): Alagar M
Keywords: Bioactive Compounds
Biological Activities
Elicitation and Synthesis of Bioactive Compounds
Science and Humanities
University: Anna University
Completed Date: 01/02/2015
Abstract: The objective of the present work is to focus on the synthesis and isolation of bioactive compounds and evaluation of their biological activities Naturally occurring bioactive compounds are isolated from animals plants newlineculture filtrates and marine sponges They function as hormones enzyme newlineinhibitors growth promoters neurotransmitters and immunomodulators etc newlineNaturally isolated cyclic heptapeptide Euryjanicin A Talaromin A newlineand B were evaluated screened for their molecular docking analysis using newlineSchrodinger tool The designed cyclic heptapeptides exhibited good docking newlinescore towards target protein for HeLa cancer cell line Based on the docking newlinescore cyclic heptapeptides were synthesized and characterized by FTIR 1H newlineNMR 13C NMR and Mass spectral analysis Further the compounds were newlineanalyzed for their antioxidant and anticancer activities The results of the newlinepresent study indicate that Euryjanicin A Talaromin A and B showed potent newlineantioxidant and anticancer activities against HeLa cancer cell lines newlineAchyranthes aspera L Amaranthaceae has long been used in newlinedifferent systems of medicine in the treatment of cancer leprosy asthma newlinefistula piles arthritis wound insect and snake bite dandruff hepatitis renal newlinedisorders dermatological disorders gynaecological disorders gonorrhea newlinemalaria fever cough diabetes pyorrhea dysentery opthalmia rabies newlinehysteria toothache etc Achyranthes aspera Linn showed various newlinepharmalogical activities like antimicrobial larvicidal antifertility immunostimulant newlinehypoglycemic hypolipidemic anti inflammatory antioxidant newlinediuretic cardiac stimulant antihypertensive anti anasacra analgesic newlineantipyretic antinoiceptive prothyrodic antispasmodic and hepatoprotective newline newline
Pagination: xxix, 229p.
Appears in Departments:Faculty of Science and Humanities

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01_title.pdfAttached File22.37 kBAdobe PDFView/Open
02_certificates.pdf894.5 kBAdobe PDFView/Open
03_abstracts.pdf9 kBAdobe PDFView/Open
04_acknowledgement.pdf4.62 kBAdobe PDFView/Open
05_contents.pdf15.81 kBAdobe PDFView/Open
06_list_of_tables.pdf5.8 kBAdobe PDFView/Open
07_list_of_figures.pdf29.7 kBAdobe PDFView/Open
08_list_of_schemes.pdf3.3 kBAdobe PDFView/Open
09_list_of_abbreviations .pdf21.29 kBAdobe PDFView/Open
10_chapter1.pdf341.98 kBAdobe PDFView/Open
11_chapter2.pdf1.25 MBAdobe PDFView/Open
12_chapter3.pdf663.91 kBAdobe PDFView/Open
13_chapter4.pdf2.15 MBAdobe PDFView/Open
14_chapter5.pdf382.26 kBAdobe PDFView/Open
15_chapter6.pdf284.1 kBAdobe PDFView/Open
16_conclusion.pdf12.11 kBAdobe PDFView/Open
17_references.pdf70.47 kBAdobe PDFView/Open
18_list_of_publications.pdf6.5 kBAdobe PDFView/Open

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