Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/11367
Title: Molecular characterization of a virus causing mosaic disease on withania somnifera
Researcher: Baghel, Geetesh
Guide(s): Qamar A. Naqvi
Keywords: Botany
Withania somnifera
virus
mosaic disease
Pharmacology
begomoviruses
Upload Date: 20-Sep-2013
University: Aligarh Muslim University
Completed Date: 2012
Abstract: Withania somnifera Locally known as ashwagandha, belongs to family Solanaceae. The plant has an important place in different medical systems (Ayurvedic, Allopathic, Unani, Homeopathic etc.) due to its excellent therapeutic properties. W. somnifera possesses a great potential for the treatment of several maladies such as inflammation, impotency, dehydration, cancer, arthritis, Parkinson s disease, rheumatism, memory loss, nervous exhaustion, bone weakness and tension, chronic fatigue, debility, premature ageing, emaciation etc. Pharmaco-chemical analysis of W. somnifera has revealed a very large number of bio-active compounds such as alkaloids and steroidal lactones. At present, 138 withanolides with both and#946; and and#945; side chains has been reported. Major source of withanolides in W. somnifera has been reported to be in its leaves possessing an excellent selective COX-2 inhibitory activity. Ethnic or aqueous extract of the root alone or in combination with other herbal materials is used in many commercial herbal formulations under various trade names such as Mentat, Gerifortate, Pepcaps, Stresscom, Ashwagandharist, Ashwagandha-ghrit etc. W. somnifera is cultivated over an area of 10,780 ha with a production of 8429 tones in India, While the annual demand increased from 7028 tones (2001-02) to 9127 tones (2004-05) necessitating the increase in its cultivation and higher production. A new virus disease was observed on W. somnifera in Aligarh, Lucknow of Uttar Pradesh and Hindaun city of Rajasthan during 2008-09 with significant (15-25%) disease incidence. The virus infection produced mosaic and leaf curl symptoms leading to the reduction in biomass and quality of W. somnifera. Keeping in view the potential of the plant, it was necessary to identify and characterize the causal virus pathogen at molecular level. The study on virus culture, transmission, host range, electron microscopic studies and molecular characterization and studies related to morphological, anatomical and biochemical alterations were performed
Pagination: 181p.
URI: http://hdl.handle.net/10603/11367
Appears in Departments:Department of Botany

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01_title.pdfAttached File67.56 kBAdobe PDFView/Open
02_certificate.pdf170.73 kBAdobe PDFView/Open
03_declaration.pdf269.9 kBAdobe PDFView/Open
04_dedication.pdf366.96 kBAdobe PDFView/Open
05_acknowledgements.pdf64.88 kBAdobe PDFView/Open
06_contents.pdf168.42 kBAdobe PDFView/Open
07_list of figures.pdf188.04 kBAdobe PDFView/Open
08_list of tables.pdf26.18 kBAdobe PDFView/Open
09_abbreviations.pdf95.61 kBAdobe PDFView/Open
10_preface.pdf93.57 kBAdobe PDFView/Open
11_chapter 1.pdf136.12 kBAdobe PDFView/Open
12_chapter 2.pdf2.14 MBAdobe PDFView/Open
13_chapter 3.pdf533.58 kBAdobe PDFView/Open
14_chapter 4.pdf13.22 MBAdobe PDFView/Open
15_chapter 5.pdf193.99 kBAdobe PDFView/Open
16_chapter 6.pdf171.64 kBAdobe PDFView/Open
17_bibliography.pdf408.53 kBAdobe PDFView/Open
18_appendix.pdf215.3 kBAdobe PDFView/Open
19_abstract.pdf168.33 kBAdobe PDFView/Open


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