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Title: Anticancer potential of Spiro-isoxazolidine derivatives of Parthenin
Researcher: Saxena, Arpita
Guide(s): Saxena, A K
Keywords: Biotechnology
Upload Date: 7-Aug-2013
University: Guru Nanak Dev University
Completed Date: 2011
Abstract: The term cancer refers to a group of diseases which share similar characteristics. newlineCancer can affect all living cells in the body, at all ages and in both genders. The newlinecausation is multifactorial and the disease process differs at different sites. Apoptosis newlinecontributes to the anti-tumor activity of many chemotherapeutic drugs. The control newlineof cancer requires the effective implementation of knowledge derived from more newlinethan two decades of successful research. Drug discovery has been an essential newlinepursuit of mankind since prehistoric times. Because of the structural and biological newlinediversity of their constituents, terrestrial plants offer a unique, renewable resource for newlinethe discovery of potential new drug entities. The most pertinent question is how to newlinefind the needle (active compound) in the haystack. Traditional chemotherapy drugs newlineare indeed toxins. Most often, they kill all dividing cells; in addition to cancer cells, newlinethese often include hair follicles and the cells lining the intestine. Parthenium newlinehysterophorus L. (congress grass, carrot weed, wild feverfew) is an exotic weed that newlinewas accidentally introduced in India in 1956 through imported food grains. It has newlinebecome a common weed causing dermatitis of epidemic proportions. Parthenin, a newlinesesquiterpene lactone, is the major toxin present in Parthenium hysterophorous. The newlinespiro derivatives of parthenin are prepared and successfully tested as anticancer newlineagents and spiro-heterocyclic derivatives of parthenin exhibited improved newlinecytotoxicity as indicated by the in vitro cell based assay. newlineSeven spiro-isoxazolidine derivatives of parthenin were screened against HL-60 cells newlineand four compounds were selected on the basis of their lower IC50 values. These four newlinecompounds were subjected to MTT assay, Hoechst staining, Cell Cycle analysis and newlineDNA fragmentation to assess their in-vitro apoptotic potential.
Pagination: 172p.
Appears in Departments:Department of Biotechnology

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01_title.pdfAttached File8.17 kBAdobe PDFView/Open
02_acknowledgement.pdf8.52 kBAdobe PDFView/Open
03_abstract.pdf63.81 kBAdobe PDFView/Open
04_contents.pdf53.12 kBAdobe PDFView/Open
05_list of table and figures.pdf85.58 kBAdobe PDFView/Open
06_chapter 1.pdf88.86 kBAdobe PDFView/Open
07_chapter 2.pdf1.76 MBAdobe PDFView/Open
08_chapter 3.pdf324.92 kBAdobe PDFView/Open
09_chapter 4.pdf24.38 MBAdobe PDFView/Open
10_chapter 5.pdf124.19 kBAdobe PDFView/Open
11_summary.pdf128.58 kBAdobe PDFView/Open
12_list of publications.pdf50.92 kBAdobe PDFView/Open
13_references.pdf119.75 kBAdobe PDFView/Open

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