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Title: Formulation and evaluation of biopolymers based Drug Delivery Systems
Researcher: Valluru Ravi
Guide(s): Pramod Kumar T M
Keywords: Pharmaceutical Sciences
Drug Delivery Systems
Pharmaceutical polymers
Upload Date: 22-Jul-2013
University: JSS University
Completed Date: 2012
Abstract: Pharmaceutical polymers are widely used to achieve taste masking; thickening (rheology modifier), gelling (controlled release), adhesion (binding), pH-dependent solubility (controlled release), controlled release (e.g., extended, pulsatile, and targeted), barrier properties (protection and packaging), enhanced stability, and improved bioavailability. Natural polysaccharides hold advantages over synthetic polymers because they are non toxic, less expensive and easily available. Natural polymers can be tailor-made for preparing drug delivery systems and thus can compete with synthetic biodegradable materials available in the market. Hence, there is a need to develop new carriers which are safe, economical and non toxic. Here, an attempt is being made for the use of natural polymers, kondagugu gum and ghatti gum as carrier/ excipient for formulation of different drug delivery systems. The aim of first study was to formulate and evaluate conventional tablets using natural, biodegradable polymers like kondagogu gum and ghatti gum. Granules were prepared for metoprolol tartarate employing kondagogu gum and ghatti gum as binders. The granules were evaluated for moisture content, angle of repose, density, Carr s index, Hausner ratio, particle size distribution and surface morphology by SEM. The granules were then compressed into tablets using a tablet compression machine and evaluated for parameters like hardness, thickness, weight variation, percent friability, disintegration and drug content. The percentage weight variation, percent friability and content of active ingredient for all the formulations were found to be well within United States Pharmacopoeia (USP) standards. The tablets prepared with kondagogu gum and ghatti gum as binders showed hardness in the range 1.8-9.1 and 2.2-10.1 Kg respectively.
Pagination: 238p.
Appears in Departments:College of Pharmacy

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01_title.pdfAttached File244.16 kBAdobe PDFView/Open
02_certificates & declarations.pdf495.71 kBAdobe PDFView/Open
03_dedication.pdf62.56 kBAdobe PDFView/Open
04_list of symbols.pdf297.18 kBAdobe PDFView/Open
05_abstract.pdf273.45 kBAdobe PDFView/Open
06_list of tables & figures.pdf513.54 kBAdobe PDFView/Open
07_acknowledgement.pdf134.35 kBAdobe PDFView/Open
08_chapter 1.pdf180.85 kBAdobe PDFView/Open
09_chapter 2.pdf200.43 kBAdobe PDFView/Open
10_chapter 3.pdf1.19 MBAdobe PDFView/Open
11_chapter 4.pdf1.03 MBAdobe PDFView/Open
12_chapter 5.pdf2.89 MBAdobe PDFView/Open
13_chapter 6.pdf322.63 kBAdobe PDFView/Open
14_references.pdf345.46 kBAdobe PDFView/Open
15_annexure 1.pdf374.48 kBAdobe PDFView/Open
16_annexure 2.pdf248.06 kBAdobe PDFView/Open
17_annexure 3.pdf251.14 kBAdobe PDFView/Open
18_annexure 4.pdf255.43 kBAdobe PDFView/Open
19_chapter pages.pdf36.81 kBAdobe PDFView/Open

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