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Title: Biological Significance of Polyherbal Formulations for Anticancer Activity
Researcher: Sumantha M.G.
Guide(s): Girisha S.T.
Keywords: cancer treatment
Prostate cancer
University: Bangalore University
Completed Date: 2015
Abstract: newlineThe antiproliferative activities from the methanolic extracts of Solanum indicum, Rhus succedanea, Rheum emodi and Gardenia gummifera were determined in cancer cell lines: human non-small cell lung carcinoma (H1975), prostate carcinoma (PC-3and DU145), colorectal carcinoma (HCT116) and malignant melanoma (A375). The in vitro antiproliferative assay revealed that S. indicum, R. succedanea, R. emodi and G. gummifera extracts exhibited inhibition with IC50 of 8.48 µg/ml, 24.5 µg/ml, 28.24 µg/ml and 28.61µg/ml respectively in DU145 cells, IC50 of 11.18 µg/ml, 11.04 µg/ml, 11.05 µg/ml and 23.03 µg/ml respectively in PC-3 cells. The extracts exhibited cytotoxicity in H1975 cells with IC50 of 9.03 µg/ml, 7.71 µg/ml, 15.95 µg/ml and 11.71 µg/ml respectively. Similarly, all the extracts showed cytotoxicity with IC50 of 17.58 µg/ml, 8.87 µg/ml, 19.31 µg/ml and 11.67 µg/ml respectively in HCT116 cells. The extracts also exhibited cytotoxicity in A375 cells with IC50 27.94 µg/ml, 13.13 µg/ml, 11.05 µg/ml and 7.816 µg/ml respectively. Results reveal that methanolic extracts of S. indicum, R. succedanea, R. emodi, and G. gummifera showed profound cytotoxicity to cancer cells and lower toxicity to normal cells. The extracts have potential for development of herbal formulations as an alternative to chemotherapeutic drugs. newline newlineCancer metastasis is refractory to most forms of chemotherapy. newlineConventional and alternative treatment/herbal remedies have been newlinedeveloped to target metastatic cancer cells in Asian countries.
Pagination: xi, 115p.
Appears in Departments:Department of Microbiology / Biotechnology

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02_ declaration.pdf121.69 kBAdobe PDFView/Open
03_certificate.pdf184.38 kBAdobe PDFView/Open
04_acknowledgements.pdf536.43 kBAdobe PDFView/Open
05_abstract.pdf774.8 kBAdobe PDFView/Open
06_table of content.pdf91.88 kBAdobe PDFView/Open
07_list of tables and figures.pdf933.94 kBAdobe PDFView/Open
08_chapter 1.pdf8.81 MBAdobe PDFView/Open
09_chapter 2.pdf6.98 MBAdobe PDFView/Open
10_chapter 3.pdf6.27 MBAdobe PDFView/Open
11_chapter 4.pdf5.09 MBAdobe PDFView/Open
12_chapter 5.pdf4.11 MBAdobe PDFView/Open
13_bibliography.pdf9.04 MBAdobe PDFView/Open
14_publications.pdf11.04 MBAdobe PDFView/Open

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